18 RESULTS
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COMMENT Besides canonical anatomical lesions linked to Aβ peptides and hyperphosphorylated tau protein, Alzheimer’s disease is also characterized by several other dysfunctions, including in Ca2+ signaling and mitophagic/autophagic function. Although it is well do
COMMENT I met Charles more than 30 years ago and thereafter we met frequently, always with great pleasure. As a young researcher, mainly trained in enzymology and cell biology, I have to admit that I considered anatomical pathology a rather static view of biologi
COMMENT This great paper is a significant step toward our understanding of senile plaques genesis. It also strengthens the view that autolysosomal and autophagic defects occur upstream of plaque formation and could contribute to their formation. Overall, these ob
COMMENT In their response to my comment, Marie and Willem wrote “In the paper presenting Aη peptides for
COMMENT Backtrack on η-secretase-derived APP fragment-related toxicity In the October 15, 2015, issue of Nature, Willem and colleagues reported a novel proteolytic cleavage of the Aβ precursor protein (APP, Willem et al., 2015). Specifically, the authors proposed
COMMENT The paper by Kwart and colleagues is a nice piece of work. By CRISP/Cas9-generated knock-in in human IPSCs, they overall confirm previous data from several independent laboratories, i.e., the deleterious influence of the β-secretase-derived APP fragment C
COMMENT This is an important paper and a significant advance in the field. The key question remaining concerns the relevance of Aβ40 and/or 42 in the etiology of the disease and whether this reflects a downstream event in the pathological process. checler 0
COMMENT The study by Sannerud and colleagues is a huge piece of work. By combining state-of-the-art cell biology techniques, it nicely delineates the specific structural properties of presenilin 1 or presenilin 2 that govern their subcellular localization and the
COMMENT This paper by Klevanski and colleagues is interesting and shows that the C-terminal domain of βAPP is important for synaptic plasticity as well as for learning- and memory-linked behaviors in mice. Several preliminary papers have indicated that APP was in
COMMENT The paper by Willem et al. is an interesting study on APP processing, showing that current canonical views about APP-related cleavage events are likely a very partial understanding of the overall process. It shows that an additional cleavage, occurring up
COMMENT The article by Ceglia and colleagues is an informative and interesting work from several vantagepoints. First is the crystal-clear demonstration that AICD controls WAVE1 expression at a transcriptional level. This adds to the increasing list of well- char
COMMENT Everybody can have an opinion about the journal’s harshness in retracting Winton et al., but none of us have access to all the elements of the inquiry that led the journal to such a decision. More importantly, this incident sheds light on the important sc
COMMENT This is an important paper. It appears as one of very few examples of delineated risk factors for AD for which a plausible function linked to Aβ degradation is clearly documented. Of most interest, obviously, is the observation that an AD-linked mutation
COMMENT The paper by Deyts and colleagues is of great interest. It shows that the C-terminal stubs derived from α- and β-secretase cleavages of APP, when accumulating, could alter various signaling pathways involving protein kinase A or GSK-3β kinases, and have f
COMMENT It is well established that p53 is an oncogene, many mutations on which are responsible for the development of various types of cancer. It has been proposed that this pathology is due to the impairment of the ability of p53 to eliminate damaged cells. Agi
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